Living with Anxiety
Do you find yourself struggling with excessive or uncontrollable worry, nervousness, restlessness, or other symptoms of anxiety? You are not alone. Anxiety is the most common type of mental health issue in the United States, and up to 20% of people suffer from an anxiety disorder in any given year.
Anxiety can significantly impact all areas of your life. People with uncontrolled anxiety are more likely to suffer from depression, substance abuse, gastrointestinal disorders, and insomnia. While there are a number of medications available to treat anxiety, they may be ineffective or cause unwanted side effects. There is a significant need for new treatment options for anxiety. Researchers are actively studying new options.
About the Study
This study is evaluating an investigational oral medicine called MM-120 (LSD D-tartrate) for generalized anxiety symptoms in adults 18 to 74 years old. Researchers will compare the safety and effectiveness of four different doses of MM-120 against a matching placebo (no active ingredient) for improving symptoms of anxiety.
LSD has been previously studied in over 1,000 adults. Results from these studies indicate that LSD is relatively safe both physiologically and psychologically when taken in an appropriate therapeutic setting. Side effects are minimal, and a single dose may provide both rapid and lasting improvement in anxiety symptoms. MM-120 is considered an investigational product because it has not been approved for use outside of clinical trials

Who Can Participate?
This study may be an option for people who
- Are 18 to 74 years old
- Are experiencing symptoms of Generalized Anxiety
- Are generally healthy
- Are willing to prevent pregnancy for themselves or a partner for the duration of the study
- Are able and willing to stop all medications affecting mood, as directed by the study doctor
- Do not have a history of psychedelic or other illicit substance use (excluding cannabis)
There are other requirements to join this clinical trial. A study team member will help determine if this study is right for you based on all participation criteria.
What to Expect
If you are eligible and choose to take part in this study, a computer will assign you by chance to receive the study drug MM-120 at one of four different dose levels, or a matching placebo (no active ingredient). You will not know what you have been assigned to receive.
You will receive a single dose of the study drug or placebo, taken as 8 oral capsules. After you take your dose, you will be monitored by staff at the study site for at least 12 hours.
You will be enrolled in the study for about 17 weeks, including a 4-week Screening Period, 4-day Baseline and Dosing Period, and a 12-week Follow-Up Period. You will need to attend at least 9 in-clinic visits during your time in the study.
The study drug or placebo will be provided at no cost to you. Additionally, reimbursement for study-related time and travel may be available.
You can choose to leave the study at any time, for any reason. Choosing not to participate in this study will not affect your future medical care.

Why Participate?
Before a potential treatment for anxiety can be approved, it must first be tested in a series of clinical trials. Clinical trials are a type of research and an essential step in the process of developing new medications. They are not possible without the participation of volunteers.
By choosing to volunteer, you will help us learn more about the safety and effectiveness of the study drug MM-120 (LSD D-tartrate) for treating the symptoms of anxiety. The results of this study may lead to additional treatment options that could help others living with anxiety in the future.